ASIS-P040, published as 8i or IACS-9571 (Palmer et al. 2016), is a potent inhibitor with affinities for tripartite motif 24 (TRIM24) and bromodomain PHD finger 1 (BRPF1) (ITC Kd= 31 nM and ITC Kd = 14 nM). TRIM24 or TIF1? promotes degradation of p53 through its RING type E3 ubiquitin ligase domain (Allton et al. 2009). It also plays a role in transcriptional regulation via its plant homeodomain and bromodomain motif. TRIM24 overexpression has been associated with poor prognosis for several cancers such as breast (Tsai et al. 2010), hepatocellular carcinoma (Liu et al. 2014), and nonsmall cell lung cancer (Li et al. 2012). BRPF1 is a subunit of monocytic leukemic zinc-finger protein (MOZ), MOZ-related factor (MORF), and histone acetyltransferase bound to ORC1 (HBO1) histone acetyltransferase complexes, promoting their assembly and enzymatic activity (Lalonde et al. 2014). BRPF1 may play a role in development (You et al. 2015) but its biological functions are largely unknown.